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This concise atlas evaluates the use of digital imaging technology, with emphasis on TelePAPology TM , for the pathological examination of gynecological problems, specifically the PAP smear. TelePAPology TM is a web-based diagnostic process allowing virtual slides to be analysed and interpreted remotely. Beginning with the historical background of the Pap test, the following chapter examines its future and the impact of digitisation and automation. Atlas of Gynecologic Cytopathology: with Histopathologic Correlations.

Listed under: cytopathology , gynecologic ; Textbook chapters: Cervix , Cytopathology , Vagina. This generously illustrated, user-friendly atlas for both cytopathologists and surgical pathologists is a practical guide to the diagnostically challenging area of cervical cytopathology.

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Not only does the Atlas feature concise, expert descriptions of the full range of cytopathologies in the gynecological tract, it also presents and contrasts problematic pathologies that can potentially lead to erroneous interpretation. Atlas of Non-Gynecologic Cytology. Cytology is a unique subspecialty in anatomic pathology, and plays a critical role in the diagnosis of a variety of benign and malignant lesions by using minimally invasive procedures, such as fine needle aspiration, brushing, washing and lavage.

Cytology not only provides an accurate diagnosis of the lesion based on the cytomorphological evaluation at cellular level, but also provides material for molecular characterization of a tumor for targeted therapy. In the era of personalized medicine, cytology has continued to grow and evolve as an important diagnostic tool. Atlas of Pulmonary Cytopathology.

Listed under: cytopathology , lung. Atlas of Pulmonary Cytopathology: With Histopathologic Correlations offers concrete diagnostic guidance for anatomic pathologists to accurately identify pulmonary disease using exfoliative and fine needle aspiration techniques. It not only illustrates the classic cytomorphology of common lung lesions, but also presents and contrasts important problem areas that can lead to erroneous interpretation.

Clearly and concisely written by leaders in the field, this volume is a practical desk reference for all facets of the diagnostically challenging areas of pulmonary cytopathology. Atlas of Salivary Gland Cytopathology with Histopathologic Correlations is a comprehensive diagnostic guide for anatomic pathologists that accurately identifies salivary gland disease using fine needle aspiration FNA. It not only illustrates the cytomorphology and histology of salivary gland specimens, but also presents and contrasts common problem areas that can lead to erroneous interpretation.

Atlas of Thyroid Cytopathology. The Atlas of Thyroid Cytopathology is a generously illustrated and user-friendly volume that serves as a desk reference and a practical guide in the diagnostically challenging area of thyroid cytopathology. The text is comprised of high-resolution color images that thoroughly illustrate the important aspects of the cytopathology of thyroid disease. Atlas of Touch Preparation Cytopathology. This is the first atlas dedicated to touch preparation cytopathology. Written by established pathologists who are at the cutting edge of this minimally-invasive practice, the Atlas of Touch Preparation Cytopathology presents a comprehensive overview and visual reference guide to the diagnostic applications of touch preparations.

This visually-stunning book reviews touch preparations corresponding to all major body systems and includes chapters on specimen handling and processing, intraoperative use during frozen sections, as well as on ancillary testing using touch preps. Listed under: cytopathology , histology. This book provides detailed information on basic and advanced laboratory techniques in histopathology and cytology.

It discusses the principles of and offers clear guidance on all routine and special laboratory techniques. In addition, it covers various advanced laboratory techniques, such as immunocytochemistry, flow cytometry, liquid based cytology, polymerase chain reaction, tissue microarray, and molecular technology.

Further, the book includes numerous color illustrations, tables and boxes to familiarize the reader with the work of a pathology laboratory. Central Nervous System Intraoperative Cytopathology. Central Nervous System Intraoperative Cytopathology covers the full spectrum of benign and malignant conditions of the CNS with emphasis on common disorders. The volume is heavily illustrated and contains useful algorithms that guide the reader through the differential diagnosis of common and uncommon entities encountered in the field of intraoperative neuro-cytopathology. Central Nervous System Intraoperative Cytopathology is a valuable quick reference for pathologists, cytopathologists, and fellows and trainees dealing with this exigent field.

Clinical Cytopathology. The Third Edition of Clinical Cytopathology: Fundamental Principles and Practice addresses the many exciting new developments in the field, and reflects the expanded role of cytologic methods in the diagnosis of disease, and in guiding the selection of the most appropriate and effective therapy measures.

Types of cytology tests used to look for cancer

Presented in rich full color, this classic text is enhanced by more than 1, color pathology images and numerous algorithms that guide you through the process of determining whether a particular disease state is present. This image-rich guide extensively covers the principles of gynecologic cytopathology and takes a thorough look at practical matters such as evaluations of patients and their specimens as well as criteria to determine specimen adequacy.

Comprehensive reviews of the morphology of the vast majority of entities both benign and malignant that are routinely identified in Pap tests are presented. Common Diagnostic Pitfalls in Thyroid Cytopathology. Listed under: cytopathology ; Textbook chapters: Cytopathology , Thyroid gland. This text provides a comprehensive review of the most frequently encountered diagnostic pitfalls in thyroid cytopathology.

Written in a case study format, the text provides the most current and complete information on both non-neoplastic and neoplastic thyroid conditions. Comprehensive Cytopathology. In the newly updated edition of Comprehensive Cytopathology, a team of international experts provides criteria and techniques in diagnosis, testing, and new insights in cytology. This accessible guide to diagnostic investigation and screening is ideal for daily laboratory use, taking a systematic approach to helping you understand major diagnostic criteria as well as the pitfalls and limitations of cytology.

Cytohistology of the Serous Membranes. Each volume in this richly illustrated series, sponsored by the Papanicolaou Society of Cytopathology, provides an organ-based approach to the cytological and histological diagnosis of small tissue samples. Benign, reactive and malignant entities are presented in a well-organized and standardized format, with high-resolution color photomicrographs, tables, tabulated specific morphologic criteria and ancillary testing algorithms.

An emerging role for cytopathology in precision oncology.

Cytology: Diagnostic Principles and Clinical Correlates. Fully updated, the 4th edition of Cytology helps you apply the latest diagnostic techniques for the interpretation of a complete range of cytological specimens. This medical reference book offers you quick access to the newest methods and adjunct tests, all in a brief, highly readable format that makes quick work of reviewing the key information available on this powerful yet minimally invasive method. It's a perfectly practical bench manual for trainees and practicing pathologists alike! Cytopathology Encyclopedia of Pathology.

This book covers the complete field of the Cytopathology - from cytological findings of Acinic cell carcinoma Disease to Warthin tumor. The alphabetically arranged entries, each of which provides a detailed description of a specific pathological disease pattern, allow readers to quickly and easily find the information they need.

Cytopathology Case Review. The cell pellet was resuspended in 0.

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In the scWB, the primary HER2-positive breast cancer cells were rapidly thawed and pelleted by centrifugation. We assayed 6 protein markers by the scWB via 3 immunoprobing rounds to identify the HER2-positive population in the heterogeneous breast tumor biopsies. The quantifiable HER2-positive cell number of each tumor is 90 cells for Tumor , cells for Tumor , 36 cells for Tumor , 10 cells for Tumor , 42 cells for Tumor , 6 cells for Tumor , 15 cells for Tumor , and four cells for the male breast tumor.

The cell number of panCK-positive cells in each tumor is listed in the Supplementary Table 1. The handling of scWB on cell lines and primary cells, including single-cell settling, in situ lysis, PAGE, photo-activated protein immobilization and immunoprobing, has been previously reported. For detecting phosphoproteins, 0. The immobilized proteins were then immunoprobed in-gel by primary and fluorescently-labeled secondary antibodies.

For protein multiplexing, the stripping and antibody reprobing procedures have been detailed previously. All images were analyzed by ImageJ 1. All plots were graphed by OriginPro 8. The guideline for scWB analysis can be found in the previously published protocol. Further, the t-erbB2 expression was quantified from AUC within a set boundary. Multiple statistical analyses were performed. The Mann-Whitney u -test was used to determine the difference in mean and distribution of two cell populations that were not necessarily normally distributed.

Cytology in the Diagnosis of Cancer

The coefficient of variation CV or variance was employed to evaluate the cell-to-cell or tumor-to-tumor variation. The F -test was used to determine the equality of variances of expressions in two cell populations. Single-cell clustering was used to identify cell subpopulations within HER2-positive breast tumors Tumor and Tumor Since the expression levels of the four proteins have been scaled and there is a small number of proteins, it is reasonable to use the Euclidian distance to assess the relationships between cells.

Correlation-based measures may be less appropriate here because of the potential large variance of correlation estimates between vectors with very low dimensions. The dendrogram and heatmap were generated with R version 3. Normalized spectral clustering was performed by using an epsilon-neighborhood graph to construct an adjacency matrix with which the Laplacian matrix was computed. The datasets produced during the current study have been deposited in the Figshare repository with the DOI: Arribas, J. Cancer Res.

Cytopathology in Oncology

Yang, C. Natl Acad.

USA , — Harper, S. VEGF-A splicing: the key to anti-angiogenic therapeutics? Cancer 8 , — Christianson, T. Anido, J. Biosynthesis of tumorigenic HER2 C-terminal fragments by alternative initiation of translation. EMBO J.

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Pedersen, K. A naturally occurring HER2 carboxy-terminal fragment promotes mammary tumor growth and metastasis. Jackson, C.