No matching affiliation detected. Find all citations in this journal default. Or filter your current search. Progress in Brain Research [01 Jan , ].
Type: Research Support, Non-U. Abstract The majority of neurons in the basal ganglia utilize GABA as their principal neurotransmitter and, as a consequence, most basal ganglia neurons receive extensive GABAergic inputs derived from multiple sources.
In order to understand the diverse roles of GABA in the basal ganglia it is necessary to define the precise localization of GABA receptors in relation to known neuron subtypes and known afferents. In each of the regions of the basal ganglia that have been studied, GABA A receptor subunits are located primarily at symmetrical synapses formed by GABAergic boutons, where they display a several-hundred-fold enrichment over extrasynaptic sites.
In contrast, GABA B receptors are widely distributed at synaptic and extrasynaptic sites on both presynaptic and postsynaptic membranes.
Presynaptic GABA B receptors are localized on striatopallidal, striatonigral and pallidonigral afferent terminals, as well as glutamatergic terminals derived from the cortex, thalamus and subthalamic nucleus. Funding Medical Research Council. Read Article at publisher's site. How does Europe PMC derive its citations network?
Protein Interactions. Nineteen mammalian subunit genes have been identified, each showing distinct regional and cell-type-specific expression.
- GABA and the Basal Ganglia: Volume 160.
- Drug Epidemiology / Pharmako-Epidemiologie: The English-German Dictionary with German-English Subject Index and Critical Appraisal Forms for Literature Review / Das englisch-deutsche Wörterbuch mit deutsch-englischem Sachregister und Formularen zur kritis.
- GABA(A) receptors: structure and function in the basal ganglia. - Abstract - Europe PMC.
The combinatorial assembly of the subunits generates considerable functional diversity. Funding Medical Research Council. G Read Article at publisher's site.
How does Europe PMC derive its citations network? Protein Interactions. Protein Families.
Nucleotide Sequences. Functional Genomics Experiments.
Localization of GABA receptors in the basal ganglia. - Semantic Scholar
Protein Structures. Gene Ontology GO Terms. Data Citations.
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